The Role of Oxidative Stress, Mitochondrial Function, and Autophagy in Diabetic Polyneuropathy

Diabetic polyneuropathy (DPN) is the most frequent and prevalent chronic complication of diabetes mellitus (DM). The state of persistent hyperglycemia leads to an increase in the production of cytosolic and mitochondrial reactive oxygen species (ROS) and favors deregulation of the antioxidant defens...

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Bibliographic Details
Published in:	Journal of Diabetes Research 2017-01, Vol.2017 (2017), p.1-15
Main Authors:	Miranda-Díaz, Alejandra Guillermina, Rodríguez-Carrizalez, Adolfo Daniel, Pacheco Moisés, Fermín Paul, Sifuentes-Franco, Sonia
Format:	Article
Language:	English
Subjects:	Animals Antioxidants Autophagy Autophagy (Cytology) Autophagy - physiology Complications and side effects Cytokines Development and progression Diabetes Diabetes mellitus Diabetic neuropathies Diabetic Neuropathies - metabolism Diabetic neuropathy Endoplasmic reticulum Glucose Health aspects Homeostasis Humans Hyperglycemia Kinases Lipids Metabolism Mitochondria Mitochondria - metabolism Mitochondrial DNA Nervous system Nitrogen dioxide Oxidative stress Oxidative Stress - physiology Physiological aspects Physiology Polyneuropathies Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Review Tumor necrosis factor-TNF
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