FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a progressive vascular remodeling disease characterized by a persistent elevation of pulmonary artery pressure, leading to right heart failure and premature death. Exaggerated proliferation and resistance to apoptosis of pulmonary artery smooth muscle cells (...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2018-02, Vol.96 (2), p.223-235
Main Authors: Bourgeois, Alice, Lambert, Caroline, Habbout, Karima, Ranchoux, Benoit, Paquet-Marceau, Stéphanie, Trinh, Isabelle, Breuils-Bonnet, Sandra, Paradis, Renée, Nadeau, Valérie, Paulin, Roxane, Provencher, Steeve, Bonnet, Sébastien, Boucherat, Olivier
Format: Article
Language:English
Subjects:
Animal models
Animals
Apoptosis
Biomedical and Life Sciences
Biomedicine
Cancer
Cell Line
Cell Proliferation
DNA repair
Forkhead Box Protein M1 - antagonists & inhibitors
Forkhead Box Protein M1 - physiology
Heart diseases
Human Genetics
Humans
Hypertension
Hypertension, Pulmonary - drug therapy
Hypertension, Pulmonary - metabolism
Hypertrophy, Right Ventricular - metabolism
Internal Medicine
Male
MicroRNAs - metabolism
Molecular Medicine
Morphogenesis
Myocytes, Smooth Muscle - physiology
Original Article
Pulmonary arteries
Pulmonary artery
Pulmonary Artery - cytology
Pulmonary Artery - physiology
Pulmonary hypertension
Rats, Sprague-Dawley
Smooth muscle
Survivin
Thiostrepton
Thiostrepton - therapeutic use
Vascular Remodeling
Veins & arteries
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