Circulating Serum 25‐Hydroxyvitamin D Levels and Bone Mineral Density: Mendelian Randomization Study

There is considerable discussion of the importance for increased serum 25‐hydroxyvitamin D (S‐25OHD) concentration associated with adequacy for bone health. Accordingly, whether long‐term high S‐25OHD concentration in general positively affects bone mineral density (BMD) is uncertain. We used a Mend...

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Bibliographic Details
Published in:Journal of bone and mineral research 2018-05, Vol.33 (5), p.840-844
Main Authors: Larsson, Susanna C, Melhus, Håkan, Michaëlsson, Karl
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Absorptiometry, Photon
Bone density
Bone Density - genetics
BONE MINERAL DENSITY
Dual energy X-ray absorptiometry
Female
Femur
Femur Neck - diagnostic imaging
Femur Neck - metabolism
Genetic factors
Humans
Long bone
Lumbar Vertebrae - diagnostic imaging
Lumbar Vertebrae - metabolism
Male
MENDELIAN RANDOMIZATION
Mendelian Randomization Analysis
OSTEOPOROSIS
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
SINGLE‐NUCLEOTIDE POLYMORPHISMS
Spine (lumbar)
Standard deviation
Statistical analysis
Ultrasound
VITAMIN D
Vitamin D - analogs & derivatives
Vitamin D - blood
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