Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response

Our genomic DNA is found predominantly in a double-stranded helical conformation. However, there are a number of cellular transactions and DNA damage events that result in the exposure of single stranded regions of DNA. DNA transactions require these regions of single stranded DNA, but they are only...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2019-02, Vol.86, p.121-128
Main Authors: Croft, Laura V., Bolderson, Emma, Adams, Mark N., El-Kamand, Serene, Kariawasam, Ruvini, Cubeddu, Liza, Gamsjaeger, Roland, Richard, Derek J.
Format: Article
Language:English
Subjects:
Cell cycle checkpoint activation
DNA repair
hSSB1
Replication fork restart
ssDNA interactions
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