Zero-inflated generalized Dirichlet multinomial regression model for microbiome compositional data analysis

There is heightened interest in using high-throughput sequencing technologies to quantify abundances of microbial taxa and linking the abundance to human diseases and traits. Proper modeling of multivariate taxon counts is essential to the power of detecting this association. Existing models are lim...

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Bibliographic Details
Published in:Biostatistics (Oxford, England) England), 2019-10, Vol.20 (4), p.698-713
Main Authors: Tang, Zheng-Zheng, Chen, Guanhua
Format: Article
Language:English
Subjects:
Biostatistics - methods
Data Analysis
Humans
Microbiota
Models, Statistical
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