Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs

Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ 1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation kinetics by trapping intermediates. Results demonstrating the red...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (91), p.12883-12886
Main Authors: Sahoo, Bikash R, Genjo, Takuya, Bekier, Michael, Cox, Sarah J, Stoddard, Andrea K, Ivanova, Magdalena, Yasuhara, Kazuma, Fierke, Carol A, Wang, Yanzhuang, Ramamoorthy, Ayyalusamy
Format: Article
Language:English
Subjects:
Agglomeration
Alzheimer disease
Alzheimer Disease - metabolism
Alzheimer Disease - pathology
amyloid beta-peptides
Amyloid beta-Peptides - chemistry
Amyloid beta-Peptides - metabolism
Amyloid beta-Peptides - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
chemical reactions
Circular Dichroism
Dimyristoylphosphatidylcholine - chemistry
Dynamic Light Scattering
Humans
Kinetics
Lipids
Microscopy, Fluorescence
Nanostructures - chemistry
neurotoxicity
Oligomers
Peptide Fragments - chemistry
Peptide Fragments - metabolism
Peptide Fragments - pharmacology
Polymethacrylic Acids - chemistry
polymethylmethacrylate
Protein Binding
Thermodynamics
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