DHS (trans−4,4′-dihydroxystilbene) suppresses DNA replication and tumor growth by inhibiting RRM2 (ribonucleotide reductase regulatory subunit M2)

DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Since inhibition of DNA replication can lead to replication fork stalling, resulting in DNA damage and apoptotic death, inhibitors of DNA replication are commonly used in cancer chemotherapy. Ribonucle...

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Bibliographic Details
Published in:	Oncogene 2019-03, Vol.38 (13), p.2364-2379
Main Authors:	Chen, Chi-Wei, Li, Yongming, Hu, Shuya, Zhou, Wei, Meng, Yunxiao, Li, Zongzhu, Zhang, Yi, Sun, Jing, Bo, Zhou, DePamphilis, Melvin L., Yen, Yun, Han, Zhiyong, Zhu, Wenge
Format:	Article
Language:	English
Subjects:	13/1 13/109 13/2 13/31 38/89 631/154/555 631/337/151 631/67/1059/153 64/60 82/1 82/80 Animal models Animals Apoptosis Cell Biology Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cisplatin Colorectal cancer Colorectal carcinoma Cyclin F Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair DNA Replication - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Female Gemcitabine Gene duplication HCT116 Cells Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Mice Mice, Nude Models, Molecular Molecular Docking Simulation Neoplasms - pathology Nucleotide analogs Oncology Ovarian cancer Pancreatic cancer Proteasomes Protein Subunits - drug effects Reductase Replication Resveratrol Ribonucleotide reductase Ribonucleotide Reductases - antagonists & inhibitors Ribonucleotide Reductases - chemistry Ribonucleotide Reductases - metabolism Stilbenes - chemistry Stilbenes - pharmacology trans-Stilbene Xenograft Model Antitumor Assays Xenografts
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