Testis Development

Abstract Production of sperm and androgens is the main function of the testis. This depends on normal development of both testicular somatic cells and germ cells. A genetic program initiated from the Y chromosome gene sex-determining region Y (SRY) directs somatic cell specification to Sertoli cells...

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Bibliographic Details
Published in:Endocrine reviews 2019-08, Vol.40 (4), p.857-905
Main Authors: Mäkelä, Juho-Antti, Koskenniemi, Jaakko J, Virtanen, Helena E, Toppari, Jorma
Format: Article
Language:English
Subjects:
Androgens
Animals
Birth defects
Care and treatment
Cell differentiation
Chromosomes
Congenital defects
Cryptorchidism
Diagnosis
Differentiation (biology)
Fetuses
Genetic research
Germ cells
Health aspects
Humans
Leydig cells
Male
Men
Mice
Pseudohermaphroditism
Sertoli cells
Sex
Sex differentiation
Sex differentiation disorders
Signal Transduction
Somatic cells
Sperm
Spermatogenesis
Spermatogonia
Stem Cells - physiology
Testes
Testis - growth & development
Testis - metabolism
Testis - physiology
Testosterone
Transcription factors
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