Measurement of Myofilament-Localized Calcium Dynamics in Adult Cardiomyocytes and the Effect of Hypertrophic Cardiomyopathy Mutations

RATIONALE:Subcellular Ca indicators have yet to be developed for the myofilament where disease mutation or small molecules may alter contractility through myofilament Ca sensitivity. Here, we develop and characterize genetically encoded Ca indicators restricted to the myofilament to directly visuali...

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Bibliographic Details
Published in:Circulation research 2019-04, Vol.124 (8), p.1228-1239
Main Authors: Sparrow, Alexander J., Sievert, Kolja, Patel, Suketu, Chang, Yu-Fen, Broyles, Connor N., Brook, Frances A., Watkins, Hugh, Geeves, Michael A., Redwood, Charles S., Robinson, Paul, Daniels, Matthew J.
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - antagonists & inhibitors
Adenosine Triphosphatases - metabolism
Adenoviridae
Animals
Benzylamines - pharmacology
Calcium - metabolism
Cardiomyopathy, Hypertrophic - genetics
Cardiomyopathy, Hypertrophic - metabolism
Cellular Biology
Guinea Pigs
In Vitro Techniques
Male
Mutation
Myocytes, Cardiac - metabolism
Myofibrils - drug effects
Myofibrils - metabolism
Myosins - drug effects
Myosins - metabolism
Sarcomeres - metabolism
Simendan - pharmacology
Transduction, Genetic - methods
Troponin I - genetics
Troponin I - metabolism
Troponin T - genetics
Troponin T - metabolism
Uracil - analogs & derivatives
Uracil - pharmacology
Urea - analogs & derivatives
Urea - pharmacology
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