Pro-inflammatory Cytokines Alter the Immunopeptidome Landscape by Modulation of HLA-B Expression

Antigen presentation on HLA molecules is a major mechanism by which the immune system monitors self and non-self-recognition. Importantly, HLA-I presentation has gained much attention through its role in eliciting anti-tumor immunity. Several determinants controlling the peptides presented on HLA ha...

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Bibliographic Details
Published in:	Frontiers in immunology 2019-02, Vol.10, p.141
Main Authors:	Javitt, Aaron, Barnea, Eilon, Kramer, Matthias P., Wolf-Levy, Hila, Levin, Yishai, Admon, Arie, Merbl, Yifat
Format:	Article
Language:	English
Subjects:	A549 Cells Antigen (tumor-associated) Antigen presentation Antigenic determinants bioinformatics cancer Cells Cytokines Haplotypes Histocompatibility antigen HLA HLA HLA-B Antigens - immunology Humans Immune system Immunity Immunology immunopeptidomics Inflammation Interferon-gamma - pharmacology Lung cancer Lung Neoplasms - immunology Mass spectrometry Metastases Microenvironments Peptides Peptides - immunology Physiology Proteins Proteome Proteomes proteomics Scientific imaging Self-recognition Tumor Necrosis Factor-alpha - pharmacology Tumors γ-Interferon
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