An update of knowledge on PD‐L1 in head and neck cancers: Physiologic, prognostic and therapeutic perspectives

Programmed cell death‐ligand 1 (PD‐L1) is a transmembrane protein that acts as a co‐inhibitory factor in the immune response. Its receptor, programmed cell death protein 1 (PD‐1), is found on immune cells, where binding to PD‐L1 can reduce the proliferation of PD‐1‐positive cells, inhibit their cyto...

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Bibliographic Details
Published in:Oral diseases 2020-04, Vol.26 (3), p.511-526
Main Authors: Lenouvel, Daniel, González‐Moles, Miguel Ángel, Talbaoui, Asmae, Ramos‐García, Pablo, González‐Ruiz, Lucía, Ruiz‐Ávila, Isabel, Gil‐Montoya, José Antonio
Format: Article
Language:English
Subjects:
Apoptosis
Cell death
Cell proliferation
Head & neck cancer
Head and neck
Immune response
Immunological tolerance
Immunotherapy
Monoclonal antibodies
Oral cancer
Oral squamous cell carcinoma
PD-L1 protein
PD‐L1
prognostic
programmed death‐ligand 1
Squamous cell carcinoma
Structure-function relationships
Therapeutic applications
therapy
Tumors
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