PRC2 is high maintenance

As the process that silences gene expression ensues during development, the stage is set for the activity of Polycomb-repressive complex 2 (PRC2) to maintain these repressed gene profiles. PRC2 catalyzes a specific histone posttranslational modification (hPTM) that fosters chromatin compaction. PRC2...

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Bibliographic Details
Published in:Genes & development 2019-08, Vol.33 (15-16), p.903-935
Main Authors: Yu, Jia-Ray, Lee, Chul-Hwan, Oksuz, Ozgur, Stafford, James M., Reinberg, Danny
Format: Article
Language:English
Subjects:
Animals
Chromatin - metabolism
Epigenesis, Genetic
Gene Expression Regulation
Humans
Mutation
Neoplasms - genetics
Neoplasms - physiopathology
Polycomb Repressive Complex 2 - genetics
Polycomb Repressive Complex 2 - metabolism
Protein Transport
Research - trends
Special Section: Review
Citations: Items that this one cites
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Online Access:Get full text
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