68 Ga-PSMA PET/CT compared with MRI/CT and diffusion-weighted MRI for primary lymph node staging prior to definitive radiotherapy in prostate cancer: a prospective diagnostic test accuracy study

• Published in: World journal of urology 2020-04, Vol.38 (4), p.939
• Main Authors: Petersen, Lars J, Nielsen, Julie B, Langkilde, Niels C, Petersen, Astrid, Afshar-Oromieh, Ali, De Souza, Nandita M, De Paepe, Katja, Fisker, Rune V, Arp, Dennis T, Carl, Jesper, Haberkorn, Uwe, Zacho, Helle D
• Format: Article
• Language: English
• Subjects: Aged; Diffusion Magnetic Resonance Imaging; Humans; Lymphatic Metastasis - diagnostic imaging; Male; Membrane Glycoproteins; Middle Aged; Multimodal Imaging; Neoplasm Staging; Organometallic Compounds; Positron Emission Tomography Computed Tomography - methods; Prospective Studies; Prostatic Neoplasms - pathology; Prostatic Neoplasms - radiotherapy; Radiopharmaceuticals; Reproducibility of Results; Tomography, X-Ray Computed
• ISSN: 1433-8726
• DOI: 10.1007/s00345-019-02846-z

The aim was to compare the diagnostic accuracy of Ga-PSMA PET/CT with conventional cross-sectional imaging and diffusion-weighted MRI (DW-MRI) for detecting lymph node metastasis (LNM) to stage prostate cancer patients. Twenty consecutive, newly- diagnosed prostate cancer patients were prospectively enrolled and underwent Ga-PSMA-11 PET/CT, anatomical MRI or contrast-enhanced CT, and DW-MRI prior to laparoscopic, template-based, extended lymph node dissection. Histopathological findings served as the reference test. Histopathology showed LNM in 13 of 20 patients (19 high-risk, 1 intermediate risk). Five patients had metastasis-suspected lymph nodes on Ga-PSMA PET/CT. Patient-based analysis showed that the sensitivity and specificity for detecting LNM were 39% and 100% with Ga-PSMA PET/CT, 8% and 100% with MRI/CT, and 36% and 83% with DW-MRI, respectively. The positive and negative predictive values were 100% and 49% with Ga-PSMA PET/C, 100% and 37% with MRI/CT, and 80% and 42% with DW-MRI. Of 573 dissected lymph nodes, 33 were LNM from 26 regions. True-positive LNM on Ga-PSMA PET/CT was 9-11 mm in diameter, whereas false-negative LNM had a median diameter of 4 mm, with only 3 of 30 lymph nodes being larger than 10 mm. LNM were positive for PSMA by immunostaining. The sensitivity of Ga-PSMA PET/CT was notably better than that of MRI/CT and comparable to that of DW-MRI. Some false positive findings with DW-MRI reduced its specificity and positive predictive value compared with those of Ga-PSMA PET/CT and MRI/CT.