The physiological role of α‐synuclein and its relationship to Parkinson’s Disease

The protein α‐synuclein has a central role in the pathogenesis of Parkinson’s disease (PD). In this review, we discuss recent results concerning its primary function, which appears to be on cell membranes. The pre‐synaptic location of synuclein has suggested a role in neurotransmitter release and it...

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Bibliographic Details
Published in:	Journal of neurochemistry 2019-09, Vol.150 (5), p.475-486
Main Authors:	Sulzer, David, Edwards, Robert H.
Format:	Article
Language:	English
Subjects:	alpha-Synuclein - chemistry alpha-Synuclein - deficiency alpha-Synuclein - genetics alpha-Synuclein - physiology Animals Axons - metabolism Cell Membrane - chemistry Cell Membrane - metabolism Cell membranes Curvature Disease Models, Animal Dopamine - metabolism Exocytosis Exocytosis - physiology fusion pore Humans Lewy pathology Membrane fusion Membrane Fusion - physiology Membranes Mice, Knockout Mice, Transgenic Mitochondria - pathology Movement disorders Mutation, Missense Neurodegenerative diseases Neurotransmitter release Neurotransmitters Parkinson Disease - metabolism Parkinson's disease Pathogenesis Peptides Presynaptic Terminals - chemistry Protein Domains Protein Folding Protein Isoforms - chemistry Protein Isoforms - physiology Recombinant Proteins - metabolism regulated exocytosis Secretory Vesicles - metabolism Secretory Vesicles - ultrastructure Synaptic transmission synaptic vesicle Synaptic vesicles Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Synuclein
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