The effect of intermittent running on biomarkers of bone turnover

Intermittent exercise might be an efficient means of exercise for improving bone strength and quality. The aim of our study was to examine the effect of intermittent running on bone turnover markers using altered exercise-to-rest intervals. Twelve males completed one control (no exercise), and three...

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Bibliographic Details
Published in:European journal of sport science 2020-05, Vol.20 (4), p.505-515
Main Authors: Evans, W., Nevill, A., McLaren, S. J., Ditroilo, M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - metabolism
bone metabolism
Bone Remodeling
Collagen Type I - metabolism
CTX-I
Healthy Volunteers
Humans
intermittent exercise
Male
mechanical loading
non-motorised treadmill
Peptide Fragments - metabolism
Peptides - metabolism
Procollagen - metabolism
Running
Young Adult
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Summary:Intermittent exercise might be an efficient means of exercise for improving bone strength and quality. The aim of our study was to examine the effect of intermittent running on bone turnover markers using altered exercise-to-rest intervals. Twelve males completed one control (no exercise), and three, 45-min intermittent protocols (5, 20, and 80 s intervals) matched for distance and speed. Fasted venous blood samples were collected at baseline, 1, 2 and 24 h post-exercise. Carboxyterminal crosslinked telopeptide (CTX-I) and procollagen type 1 amino-terminal propeptide (P1NP) were used as markers of bone resorption and formation. After adjustment for baseline, CTX-I concentration at 1 h was higher (very likely to most likely small) for 5 s (30.2%; ±90% confidence limits: 10%), 20 s (2.9.0%; ±10%) and 80 s (32.0%; ±10%) compared to control. The very likely small effect remained for 5 s at 2 h (30.2%; ±15%). The effect for 20 and 80 s was possibly trivial and possibly small/possibly trivial (∼14.5%; ±∼15%). Differences in P1NP concentrations were likely to very likely trivial (∼7.4%; ±∼7.6%). Circulating CTX-I concentration is affected acutely by intermittent running with short-interval (5 s) intermittent loading resulting in a prolonged attenuation in circadian rhythm of CTX-I up to 2 h that was not demonstrated as clearly by longer intervals despite matched internal and external training load.
ISSN:1746-1391
1536-7290
DOI:10.1080/17461391.2019.1646811