Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in cancer cell apoptosis in response to chemotherapy....

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Bibliographic Details
Published in:	Journal of lipid research 2019-09, Vol.60 (9), p.1590-1602
Main Authors:	Kao, Li-Pin, Morad, Samy A.F., Davis, Traci S., MacDougall, Matthew R., Kassai, Miki, Abdelmageed, Noha, Fox, Todd E., Kester, Mark, Loughran, Thomas P., Abad, Jose' L., Fabrias, Gemma, Tan, Su-Fern, Feith, David J., Claxton, David F., Spiegel, Sarah, Fisher-Wellman, Kelsey H., Cabot, Myles C.
Format:	Article
Language:	English
Subjects:	Amides - pharmacology Apoptosis - drug effects cancer Cell Survival - drug effects Ceramidases - metabolism ceramide Ceramides - metabolism drug resistance Fatty Acids, Unsaturated - pharmacology Glucosyltransferases - metabolism HL-60 Cells Humans Immunoblotting Lysophospholipids - metabolism Mass Spectrometry Mitochondria - metabolism Reverse Transcriptase Polymerase Chain Reaction sphingolipids Sphingolipids - metabolism Sphingosine - analogs & derivatives Sphingosine - metabolism
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