Impaired dopamine metabolism in Parkinson’s disease pathogenesis

A full understanding of Parkinson’s Disease etiopathogenesis and of the causes of the preferential vulnerability of nigrostriatal dopaminergic neurons is still an unsolved puzzle. A multiple-hit hypothesis has been proposed, which may explain the convergence of familial, environmental and idiopathic...

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Bibliographic Details
Published in:	Molecular neurodegeneration 2019-08, Vol.14 (1), p.35-21, Article 35
Main Authors:	Masato, Anna, Plotegher, Nicoletta, Boassa, Daniela, Bubacco, Luigi
Format:	Article
Language:	English
Subjects:	Aldehyde dehydrogenase Aldehydes Amine oxidase (flavin-containing) Basal ganglia Biomedical and Life Sciences Biomedicine Cardiotonic agents Care and treatment Catechin Catechol Cell death Central nervous system diseases Degeneration Dehydrogenases Disease Disease susceptibility DOPAL Dopamine Dopamine receptors Enzymes Genetic diversity Hypotheses Metabolism Metabolites Molecular Medicine Monoamine oxidase Movement disorders Mutation Nervous system Neurodegeneration Neurodegenerative diseases Neurology Neurons Neurosciences Neurotoxicity Oligomerization Oligomers Oxidases Oxidative stress Oxidoreductases Parkinson disease Parkinson's disease Pathogenesis Pathology Phenols (Class of compounds) Phosphorylation Physiology Protein interaction Resveratrol Review Risk factors Selective vulnerability Substantia nigra Synapses Synaptic vesicles αSynuclein
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