Separate modeling of cortical and trabecular bone offers little improvement in FE predictions of local structural stiffness at the proximal tibia

Quantitative computed tomography-based finite element (QCT-FE) modeling has potential to clarify the role of altered subchondral bone stiffness in osteoarthritis. The objective of this research was to evaluate different QCT-FE modeling and thresholding approaches to identify the method which best pr...

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Bibliographic Details
Published in:Computer methods in biomechanics and biomedical engineering 2019-12, Vol.22 (16), p.1258-1268
Main Authors: Hosseini Kalajahi, S. Mehrdad, Nazemi, S. Majid, Johnston, James D.
Format: Article
Language:English
Subjects:
Amputation
Biomedical materials
Cancellous bone
Computed tomography
Cortical bone
Finite element method
Finite element modeling
Iron
Knee
Mathematical models
Mechanical properties
Modelling
Osteoarthritis
Predictions
proximal tibia
quantitative computed tomography
Stiffness
Subchondral bone
subchondral bone stiffness
Tibia
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Summary:Quantitative computed tomography-based finite element (QCT-FE) modeling has potential to clarify the role of altered subchondral bone stiffness in osteoarthritis. The objective of this research was to evaluate different QCT-FE modeling and thresholding approaches to identify the method which best predicted experimentally measured local subchondral structural stiffness with highest explained variance and least error. Our results showed that separate modeling of proximal tibial cortical and trabecular bone offered little improvement in QCT-FE-predicted stiffness (0% to +3% improvement in explained variance) when compared to modeling the proximal tibia as a single structure. Based on the results of this study, we do not recommend separate modeling of cortical bone and trabecular bone when developing QCT-FE models of the proximal tibia for predicting subchondral bone stiffness.
ISSN:1025-5842
1476-8259
DOI:10.1080/10255842.2019.1661386