DCO 2 /PaCO 2 correlation on high-frequency oscillatory ventilation combined with volume guarantee using increasing frequencies in an animal model

• Published in: European journal of pediatrics 2020-03, Vol.179 (3), p.499
• Main Authors: González-Pacheco, Noelia, Sánchez-Luna, Manuel, Arribas-Sánchez, Cristina, Santos-González, Martín, Orden-Quinto, Cristina, Tendillo-Cortijo, Francisco
• Format: Article
• Language: English
• ISSN: 1432-1076

To examine the correlation DCO /PaCO on high-frequency oscillatory ventilation (HFOV) combined with volume guarantee (VG) throughout increasing frequencies in two different respiratory conditions, physiological and low compliance. Neonatal animal model was used, before and after a bronchoalveolar lavage (BAL). HFOV combined with VG was used. The frequency was increased from 10 to 20 Hz, and high-frequency tidal volume (VThf) was gradually decreased maintaining a constant DCO . Arterial partial pressure of carbon dioxide (PaCO ) was evaluated after each frequency and VThf change. Six 2-day-old piglets were studied. A linear decrease in PaCO was observed throughout increasing frequencies in both respiratory conditions while maintaining a constant DCO , showing a significant difference between the initial PaCO (at 10 Hz) and the PaCO obtained at 18 and 20 Hz. A new DCO equation (corrected DCO ) was calculated in order to better define the correlation between DCO and the observed PaCO .Conclusion: The correlation DCO /PaCO throughout increasing frequencies is not linear, showing a greater CO elimination efficiency at higher frequencies, in spite of maintaining a constant DCO . So, using frequencies close to the resonant frequency of the respiratory system on HFOV combined with VG, optimizes the efficiency of gas exchange.What is Known: • The efficacy of CO removal during high-frequency oscillatory ventilation (HFOV), described as the diffusion coefficient of CO (DCO ) is related to the square of the high-frequency tidal volume (VThf) and the frequency (f), expressed as DCO = VThf × f.What is New: • The correlation between DCO and PaCO throughout increasing frequencies is not linear, showing a greater CO elimination efficiency at higher frequencies. So, using very high frequencies on HFOV combined with volume guarantee optimizes the efficiency of gas exchange allowing to minimize lung injury.