Effect of whole soy and purified daidzein on androgenic hormones in chinese equol-producing post-menopausal women: a six-month randomised, double-blinded and Placebo-Controlled trial

A randomised, double-blind and placebo-controlled trial was performed to examine the effects of whole soy and isoflavone daidzein on serum androgenic hormones in Chinese equol-producing post-menopausal women. A total of 270 eligible women aged 45-70 years were randomised to either one of the three i...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2020-07, Vol.71 (5), p.644-652
Main Authors: Liu, Zhao-min, Li, Guoyi, Zhang, Di, Ho, Suzanne C., Chen, Yu-ming, Ma, Jing, Huang, Qi, Li, Shuyi, Ling, Wen-hua
Format: Article
Language:English
Subjects:
androgenic hormones
Androgens - blood
Androstenedione
Androstenedione - blood
China
Daidzein
Dehydroepiandrosterone
Double-Blind Method
Equol - metabolism
equol producers
Female
Food science
Globulins
Glycine max - chemistry
Health risk assessment
Hormones
Humans
Isoflavones
Isoflavones - pharmacology
Menopause
Middle Aged
Milk
Phytoestrogens - pharmacology
Plant Extracts - pharmacology
post-menopausal women
Post-menopause
Postmenopause
Prolactin
Randomization
Sex hormones
Soy Foods
Testosterone
Testosterone - blood
Whole soy
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Summary:A randomised, double-blind and placebo-controlled trial was performed to examine the effects of whole soy and isoflavone daidzein on serum androgenic hormones in Chinese equol-producing post-menopausal women. A total of 270 eligible women aged 45-70 years were randomised to either one of the three iso-caloric supplements: 40 g soy flour (whole soy group), 40 g low-fat milk powder +63 mg daidzein (daidzein group) or 40 g low-fat milk powder (placebo group) daily for 6 months. Fasting venous samples were tested for serum androstenedione (AD), testosterone (T), prolactin, sex hormone binding globulin and dehydroepiandrosterone sulphate. Intention-to-treat analysis indicated that serum T (p = .022) and AD (p = .05) levels modestly but significantly decreased after 6-month daidzein treatment in comparison with placebo, with a mean difference of -0.057 nmol/L (95%CI: -0.185 to 0.070, p = .018) and -0.118 ng/mL (95%CI: -0.240-0.004, p = .045), respectively. This 6-month trial suggested that purified daidzein may exhibit less androgenic effect. Trial registration: The trial was registered in ClinicalTrials.gov with identifier of NCT01270737. (URL: http://clinicaltrials.gov/ct2/show/NCT01270737 .)
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2020.1712682