Engulfment and cannibalism drive persistence of chemotherapy-treated tumor cells: can they be targeted?

The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel phenotype that allows cannibalism of entire cell...

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Bibliographic Details
Published in:Molecular & cellular oncology 2020-01, Vol.7 (1), p.1688601-1688601
Main Authors: Tonnessen-Murray, Crystal A., Jackson, James G.
Format: Article
Language:English
Subjects:
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Breast cancer
cannibalism
chemotherapy
engulfment
phagocytosis
SASP
senescence
survival
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Summary:The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel phenotype that allows cannibalism of entire cells and engulfment of other substrates.
ISSN:2372-3556
2372-3556
DOI:10.1080/23723556.2019.1688601