PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

Glioblastoma is a universally lethal form of brain cancer that exhibits an array of pathophysiological phenotypes, many of which are mediated by interactions with the neuronal microenvironment 1 , 2 . Recent studies have shown that increases in neuronal activity have an important role in the prolife...

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Bibliographic Details
Published in:	Nature (London) 2020-02, Vol.578 (7793), p.166-171
Main Authors:	Yu, Kwanha, Lin, Chia-Ching John, Hatcher, Asante, Lozzi, Brittney, Kong, Kathleen, Huang-Hobbs, Emmet, Cheng, Yi-Ting, Beechar, Vivek B., Zhu, Wenyi, Zhang, Yiqun, Chen, Fengju, Mills, Gordon B., Mohila, Carrie A., Creighton, Chad J., Noebels, Jeffrey L., Scott, Kenneth L., Deneen, Benjamin
Format:	Article
Language:	English
Subjects:	38 38/91 631/378/1697 631/67/1922 64 64/60 Animals Brain Brain cancer Brain Neoplasms - enzymology Brain Neoplasms - pathology Brain tumors Carcinogenesis - genetics Carcinogenesis - metabolism Class I Phosphatidylinositol 3-Kinases - chemistry Class I Phosphatidylinositol 3-Kinases - genetics Class I Phosphatidylinositol 3-Kinases - metabolism Crosstalk Disease Models, Animal Divergence Electroencephalography Genes Genomics Glioblastoma Glioblastoma - enzymology Glioblastoma - pathology Glypicans - metabolism Heparan sulfate proteoglycans Humanities and Social Sciences Hyperactivity Mice multidisciplinary Mutation Phenotypes Science Science (multidisciplinary) Tumorigenesis Tumors
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