To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis: HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Background Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, mo...

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Published in:	Current controlled trials in cardiovascular medicine 2020-02, Vol.21 (1), p.147-19, Article 147
Main Authors:	Begemann, Marieke J. H., Thompson, Ilse A., Veling, Wim, Gangadin, Shiral S., Geraets, Chris N. W., van ‘t Hag, Erna, Müller-Kuperus, Sanne J., Oomen, Priscilla P., Voppel, Alban E., van der Gaag, Mark, Kikkert, Martijn J., Van Os, Jim, Smit, H. Filip E., Knegtering, Rikus H., Wiersma, Sybren, Stouten, Luyken H., Gijsman, Harm J., Wunderink, Lex, Staring, Anton B. P., Veerman, Selene R. T., Mahabir, Amrita G. S., Kurkamp, Jörg, Pijnenborg, Gerdina H. M., Veen, Natalie D., Marcelis, Machteld, Grootens, Koen P., Faber, Gunnar, van Beveren, Nico J., Been, Agaath, van den Brink, Truus, Bak, Maarten, van Amelsvoort, Therese A. M. J., Ruissen, Andrea, Blanke, Christine, Groen, Karin, de Haan, Lieuwe, Sommer, Iris E. C.
Format:	Article
Language:	English
Subjects:	Adolescent Adult Antipsychotic agents Antipsychotic Agents - administration & dosage Antipsychotic Agents - standards Antipsychotic medication, first episode psychosis Antipsychotics Biomedicine Care and treatment Clinical outcomes Clinical trials Cognition & reasoning Comparative analysis Discontinuation Dopamine Dose-Response Relationship, Drug Drug Administration Schedule Drug dosages Female Follow-Up Studies Health Sciences Humans Maintenance Male Medical research Medicine Medicine & Public Health Middle Aged Multicenter Studies as Topic Practice Guidelines as Topic Pragmatic Clinical Trials as Topic Psychosis Psychotic Disorders - diagnosis Psychotic Disorders - drug therapy Psychotropic drugs Quality of Life Randomized controlled trial Remission (Medicine) Remission Induction - methods Schizophrenia Severity of Illness Index Single-Blind Method Statistics for Life Sciences Study Protocol Suicides & suicide attempts Tapering, global functioning Treatment Treatment Outcome Violence Young Adult
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