Sensory Ganglia-Specific TNF Expression Is Associated With Persistent Nociception After Resolution of Inflammation

Joint pain is a distressing symptom of arthritis, and it is frequently persistent even after treatments which reduce local inflammation. Continuous production of algogenic factors activate/sensitize nociceptors in the joint structures and contribute to persistent pain, a challenging and difficult co...

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Bibliographic Details
Published in:Frontiers in immunology 2020-01, Vol.10, p.3120
Main Authors: Gonçalves, William Antonio, Rezende, Barbara Maximino, Oliveira, Marcos Paulo Esteves de, Ribeiro, Lucas Secchim, Fattori, Victor, Silva, Walison Nunes da, Prazeres, Pedro Henrique Dias Moura, Queiroz-Junior, Celso Martins, Santana, Karina Talita de Oliveira, Costa, Walyson Coelho, Beltrami, Vinícius Amorim, Costa, Vivian Vasconcelos, Birbrair, Alexander, Verri, Waldiceu A., Lopes, Fernando, Cunha, Thiago Mattar, Teixeira, Mauro Martins, Amaral, Flávio Almeida, Pinho, Vanessa
Format: Article
Language:English
Subjects:
Animals
Antigens
Arthralgia
Arthritis
Cell activation
Cyclooxygenase-2
Cytokines
Dorsal root ganglia
Etanercept
Gene expression
Hyperalgesia
Immunology
Inflammation
Ketamine
Knee
Leukocytes
Leukocytes (neutrophilic)
Macrophages
Medical treatment
Microscopy
Nervous system
neuroinflammation
Neutrophils
Nitric-oxide synthase
Nociceptors
Pain
Pain perception
Proteins
resolution of inflammation
Sensory neurons
Spinal cord
TNF
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