Reactive oxygen species (ROS)-responsive ferrocene-polymer-based nanoparticles for controlled release of drugs

Ferrocene-containing nanoparticles show reversible redox activity that could trigger drug release mediated by reactive oxygen species (ROS). In this study, four ferrocene-containing polymers, comprising ferrocenylmethyl methacrylate (FMMA)-methacrylic acid (MA) random copolymers, i.e. , poly(FMMA- r...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-03, Vol.8 (9), p.196-1913
Main Authors: Na, Yoonhee, Lee, Jin Sil, Woo, Jiseob, Ahn, Sukyung, Lee, Eunhye, Il Choi, Won, Sung, Daekyung
Format: Article
Language:English
Subjects:
Animals
Controlled release
Drug carriers
Drug delivery
Drug delivery systems
Drug Liberation
Ferrous Compounds - chemistry
Fluorescent Dyes - chemistry
Hydrogen peroxide
Metallocenes - chemistry
Methacrylic acid
Mice
Molecular Structure
Nanoparticles
Nanoparticles - chemistry
NIH 3T3 Cells
Oxazines - chemistry
Oxidants
Oxidizing agents
Particle Size
Polymerization
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Reactive oxygen species
Reactive Oxygen Species - chemistry
Reactive Oxygen Species - metabolism
Self-assembly
Surface Properties
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Summary:Ferrocene-containing nanoparticles show reversible redox activity that could trigger drug release mediated by reactive oxygen species (ROS). In this study, four ferrocene-containing polymers, comprising ferrocenylmethyl methacrylate (FMMA)-methacrylic acid (MA) random copolymers, i.e. , poly(FMMA- r -MA), were synthesized via radical polymerization, resulting in self-assembled ferrocene nanoparticles (FNPs) with outstanding performance in environments in which ROS are present. These spherical FNPs have tunable diameters ranging from 270 nm to 180 nm and surface charges from −20 mV to −50 mV. Importantly, the diameters and surface charges of the FNPs changed dramatically after 2 h of post-treatment using 0.4 M hydrogen peroxide (H 2 O 2 ) as the oxidant, indicating that the FNPs were highly ROS-sensitive. Furthermore, the controlled release of a model drug from the FNPs, reflected in the release profiles, indicates that these novel FNPs could be potentially used as drug carriers for the effective therapy of ROS-related diseases such as cancer and inflammation. Ferrocene-containing nanoparticles show reversible redox activity that could trigger drug release mediated by reactive oxygen species (ROS).
ISSN:2050-750X
2050-7518
DOI:10.1039/c9tb02533b