Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial

IMPORTANCE: Intravenous thrombolysis with tenecteplase improves reperfusion prior to endovascular thrombectomy for ischemic stroke compared with alteplase. OBJECTIVE: To determine whether 0.40 mg/kg of tenecteplase safely improves reperfusion before endovascular thrombectomy vs 0.25 mg/kg of tenecte...

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Published in:	JAMA : the journal of the American Medical Association 2020-04, Vol.323 (13), p.1257-1265
Main Authors:	Campbell, Bruce C. V, Mitchell, Peter J, Churilov, Leonid, Yassi, Nawaf, Kleinig, Timothy J, Dowling, Richard J, Yan, Bernard, Bush, Steven J, Thijs, Vincent, Scroop, Rebecca, Simpson, Marion, Brooks, Mark, Asadi, Hamed, Wu, Teddy Y, Shah, Darshan G, Wijeratne, Tissa, Zhao, Henry, Alemseged, Fana, Ng, Felix, Bailey, Peter, Rice, Henry, de Villiers, Laetitia, Dewey, Helen M, Choi, Philip M. C, Brown, Helen, Redmond, Kendal, Leggett, David, Fink, John N, Collecutt, Wayne, Kraemer, Thomas, Krause, Martin, Cordato, Dennis, Field, Deborah, Ma, Henry, O’Brien, Bill, Clissold, Benjamin, Miteff, Ferdinand, Clissold, Anna, Cloud, Geoffrey C, Bolitho, Leslie E, Bonavia, Luke, Bhattacharya, Arup, Wright, Alistair, Mamun, Abul, O’Rourke, Fintan, Worthington, John, Wong, Andrew A, Levi, Christopher R, Bladin, Christopher F, Sharma, Gagan, Desmond, Patricia M, Parsons, Mark W, Donnan, Geoffrey A, Davis, Stephen M
Format:	Article
Language:	English
Subjects:	Aged Aged, 80 and over Blood vessels Brain Ischemia - drug therapy Cardiovascular system Cerebral blood flow Clinical trials Dose-Response Relationship, Drug Female Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Hemorrhage Humans Intravenous administration Ischemia Male Middle Aged Occlusion Online First Original Investigation Patients Reperfusion Reperfusion - methods Risk Stroke Stroke - drug therapy Stroke - surgery Tenecteplase - administration & dosage Tenecteplase - adverse effects Territory Thrombectomy Thrombolysis Thrombolytic drugs Treatment Outcome
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