TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis

TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is implicated in myeloid malignancies with deletion of chromosome 5q. Employing a combination of proteomic and genetic approaches, we find that TIFAB regulates ubiquitin-specific peptidase 15 (USP15) ubiquitin hydrolase activity. E...

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Bibliographic Details
Published in:Cell reports (Cambridge) 2020-02, Vol.30 (8), p.2776-2790.e6
Main Authors: Niederkorn, Madeline, Hueneman, Kathleen, Choi, Kwangmin, Varney, Melinda E., Romano, Laurel, Pujato, Mario A., Greis, Kenneth D., Inoue, Jun-ichiro, Meetei, Ruhikanta, Starczynowski, Daniel T.
Format: Article
Language:English
Subjects:
AML
Animals
Catalytic Domain
Cell Line, Tumor
Disease Models, Animal
DUB
HEK293 Cells
Hematopoiesis
Hematopoietic Stem Cells - metabolism
Humans
Intracellular Signaling Peptides and Proteins - metabolism
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - pathology
Mice
Myeloid-Lymphoid Leukemia Protein - metabolism
p53
Protein Binding
Signal Transduction
Stress, Physiological
TIFA
TIFAB
TRAF6
Tumor Suppressor Protein p53 - metabolism
Ubiquitin - metabolism
Ubiquitin-Specific Proteases - chemistry
Ubiquitin-Specific Proteases - metabolism
Ubiquitination
USP15
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