Biophysical characterisation of DNA origami nanostructures reveals inaccessibility to intercalation binding sites

Intercalation of drug molecules into synthetic DNA nanostructures formed through self-assembled origami has been postulated as a valuable future method for targeted drug delivery. This is due to the excellent biocompatibility of synthetic DNA nanostructures, and high potential for flexible programma...

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Bibliographic Details
Published in:Nanotechnology 2020-03, Vol.31 (23), p.235605
Main Authors: Miller, Helen L, Contera, Sonia, Wollman, Adam J M, Hirst, Adam, Dunn, Katherine E, Schröter, Sandra, O'Connell, Deborah, Leake, Mark C
Format: Article
Language:English
Subjects:
acridine orange
DNA damage
DNA origami
low temperature plasma
single-molecule microscopy
YOYO-1
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