Evaluation of factors affecting morbidity and mortality in pneumonectomy patients

The aim of this study was to evaluate risk factors associated with morbidity and mortality after pneumonectomy in non-small cell lung cancer patients. The study included 107 patients who underwent pneumonectomy for non-small cell lung cancer between January 2013 and December 2018. Prognostic factors...

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Bibliographic Details
Published in:Acta chirurgica belgica 2021-09, Vol.121 (5), p.301-307
Main Authors: Dogru, Mustafa Vedat, Sezen, Celal Buğra, Aker, Cemal, Girgin, Oğuz, Kilimci, Umut, Erduhan, Semih, Metin, Muzaffer
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Non-Small-Cell Lung - surgery
Female
Humans
Lung Neoplasms - surgery
Male
Middle Aged
Morbidity
mortality
non-small cell lung cancer
Pneumonectomy
Postoperative Complications - epidemiology
Retrospective Studies
Risk Factors
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Summary:The aim of this study was to evaluate risk factors associated with morbidity and mortality after pneumonectomy in non-small cell lung cancer patients. The study included 107 patients who underwent pneumonectomy for non-small cell lung cancer between January 2013 and December 2018. Prognostic factors affecting mortality and morbidity were investigated. The patient group included 10 women (9.3%) and 97 men (90.7%) with a mean age of 59.5 ± 8.5 years. Seventy-three patients (68.2%) underwent standard pneumonectomy and 34 (31.8%) underwent extended pneumonectomy. Nine patients (8.4%) received induction chemotherapy. Complications occurred in 33 patients (30.8%). Complications were classified as surgical, cardiovascular, pulmonary, or infectious. Charlson Comorbidity Index (CCI) > 3 and right-side resection were significant risk factors for the development of complications. The most common complication was atrial fibrillation. Eleven patients developed a bronchopleural fistula. The 30-day postoperative mortality rate was 6.5% (n = 7). Mortality was not associated with any demographic and surgical characteristics other than CCI > 3 (p = .05). The results of this study indicate that our pneumonectomy outcomes are acceptable despite high morbidity and mortality rates. Appropriate patient selection for pneumonectomy is as important as complication management. High-comorbidity patients should undergo these procedures in experienced centers.
ISSN:0001-5458
DOI:10.1080/00015458.2020.1753147