Prolonged inhibitory effects against planktonic growth, adherence, and biofilm formation of pathogens causing ventilator-associated pneumonia using a novel polyamide/silver nanoparticle composite-coated endotracheal tube

Microbial cells can rapidly form biofilm on endotracheal tubes (ETT) causing ventilator-associated pneumonia, a serious complication in patients receiving mechanical ventilation. A novel polyamide with a good balance of hydrophilic/hydrophobic moieties was used for the embedment of green-reduction s...

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Bibliographic Details
Published in:Biofouling (Chur, Switzerland) Switzerland), 2020-03, Vol.36 (3), p.292-307
Main Authors: Lethongkam, Sakkarin, Daengngam, Chalongrat, Tansakul, Chittreeya, Siri, Ratchaneewan, Chumpraman, Apisit, Phengmak, Manthana, Voravuthikunchai, Supayang P.
Format: Article
Language:English
Subjects:
Adhesion
Antimicrobial activity
Bacteria
bacterial adhesion
biofilm
Biofilms
Cell adhesion
Cell adhesion & migration
Coating
Coatings
Disease resistance
endotracheal tube
Gram-negative bacteria
Growth
Hydrophobicity
Incubation period
Mechanical ventilation
Microorganisms
Nanoparticles
Pathogens
Pneumonia
polyamide
Polyamide resins
Polyamides
Pseudomonas aeruginosa
Silver
silver nanoparticles
Tubes
Ventilation
Ventilator-associated pneumonia
Ventilators
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Summary:Microbial cells can rapidly form biofilm on endotracheal tubes (ETT) causing ventilator-associated pneumonia, a serious complication in patients receiving mechanical ventilation. A novel polyamide with a good balance of hydrophilic/hydrophobic moieties was used for the embedment of green-reduction silver nanoparticles (AgNPs) for the composite-coated ETT. The films were conformal with a thickness of ∼ 17 ± 3 µm accommodating high loading of 60 ± 35 nm spherical-shaped AgNPs. The coated ETT resulted in a significant difference in reducing both planktonic growth and microbial adhesion of single and mixed-species cultures, compared with uncoated ETT (p  96% after incubation for 72 h. Polyamide/AgNP composite-coated ETT provided a broad-spectrum activity against both Gram-positive and Gram-negative bacteria as well as Candida albicans and prolonged antimicrobial activity.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2020.1759041