Adaptive laboratory evolution enhances methanol tolerance and conversion in engineered Corynebacterium glutamicum

Synthetic methylotrophy has recently been intensively studied to achieve methanol-based biomanufacturing of fuels and chemicals. However, attempts to engineer platform microorganisms to utilize methanol mainly focus on enzyme and pathway engineering. Herein, we enhanced methanol bioconversion of syn...

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Bibliographic Details
Published in:Communications biology 2020-05, Vol.3 (1), p.217, Article 217
Main Authors: Wang, Yu, Fan, Liwen, Tuyishime, Philibert, Liu, Jiao, Zhang, Kun, Gao, Ning, Zhang, Zhihui, Ni, Xiaomeng, Feng, Jinhui, Yuan, Qianqian, Ma, Hongwu, Zheng, Ping, Sun, Jibin, Ma, Yanhe
Format: Article
Language:English
Subjects:
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Amino acids
Bioconversion
Biology
Biomedical and Life Sciences
Biosynthesis
Corynebacterium glutamicum
Directed evolution
Gene expression
Glycolysis
Laboratories
Life Sciences
Metabolism
Methanol
Methionine
Oxidative phosphorylation
Phosphorylation
Sulfhydrylase
Tricarboxylic acid cycle
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