Metabolic alterations in the tumor microenvironment and their role in oncogenesis

Metabolic reprogramming is a characteristic feature of both cancer cells and their neighbouring cells in the tumor microenvironment (TME). The latter include stroma fibroblasts and adipocytes, that respectively differentiate to become cancer associated fibroblasts (CAFs) and cancer associated adipoc...

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Bibliographic Details
Published in:Cancer letters 2020-08, Vol.484, p.65-71
Main Authors: Eisenberg, Lihie, Eisenberg-Bord, Michal, Eisenberg-Lerner, Avital, Sagi-Eisenberg, Ronit
Format: Article
Language:English
Subjects:
Adenosine
Adenosine - metabolism
Adipocytes
Adipocytes - metabolism
Aerobic glycolysis
Amino acids
Apoptosis
Autophagy
Cancer
Cancer-Associated Fibroblasts - metabolism
Carcinogenesis - metabolism
Cell cycle
Cell growth
Dehydrogenases
Enzymes
Fibroblasts
Genes
Glucose
Glucose metabolism
Glycolysis
Growth factors
Humans
Kinases
Lung cancer
Lysophosphatidic acid
Lysophosphatidic acid (LPA)
Lysophospholipids - metabolism
Metabolic reprogramming
Metabolism
Metabolites
Mitochondria
Mutation
Neoplasms - metabolism
Neoplasms - pathology
Oncometabolites
Phosphorylation
Proteins
Signal Transduction
Stromal cells
Tumor Microenvironment
Tumorigenesis
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