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Association of vitamin D 2 and D 3 with type 2 diabetes complications
Vitamin D measurement is a composite of vitamin D (25(OH)D ) and D (25(OH)D ) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D supplements. This study was undertaken to determine if...
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| Published in: | BMC endocrine disorders 2020-05, Vol.20 (1), p.65 |
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| container_title | BMC endocrine disorders |
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| creator | Ahmed, Lina H M Butler, Alexandra E Dargham, Soha R Latif, Aishah Robay, Amal Chidiac, Omar M Jayyousi, Amin Al Suwaidi, Jassim Crystal, Ronald G Atkin, Stephen L Abi Khalil, Charbel |
| description | Vitamin D measurement is a composite of vitamin D
(25(OH)D
) and D
(25(OH)D
) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D
supplements. This study was undertaken to determine if vitamin D
and D
levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D
and vitamin D
levels in subjects with T2DM
METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D
and D
were measured by LC-MS/MS analysis.
All subjects were taking vitamin D
and none were taking D
supplements. Vitamin D
levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p |
| format | article |
| fullrecord | <record><control><sourceid>pubmed</sourceid><recordid>TN_cdi_pubmed_primary_32414363</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>32414363</sourcerecordid><originalsourceid>FETCH-pubmed_primary_324143633</originalsourceid><addsrcrecordid>eNqFjdsKgkAURYcg0i6_EOcHBJ0Z1Ncoow_oXUYd6YRzwTMV_n0S9dzTgs3arAWLM1nwJC-5iNia6J6mWVHydMUiwWUmRS5iVh2IXIsqoLPgenhiUAYtnICDst1MAS8MNwiT1_PWoWp00AStM37A9nOkLVv2aiC9-3LD9ufqerwk_tEY3dV-RKPGqf51xV_hDTKWNrY</addsrcrecordid><sourcetype>Index Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Association of vitamin D 2 and D 3 with type 2 diabetes complications</title><source>ProQuest - Publicly Available Content Database</source><source>PubMed Central</source><creator>Ahmed, Lina H M ; Butler, Alexandra E ; Dargham, Soha R ; Latif, Aishah ; Robay, Amal ; Chidiac, Omar M ; Jayyousi, Amin ; Al Suwaidi, Jassim ; Crystal, Ronald G ; Atkin, Stephen L ; Abi Khalil, Charbel</creator><creatorcontrib>Ahmed, Lina H M ; Butler, Alexandra E ; Dargham, Soha R ; Latif, Aishah ; Robay, Amal ; Chidiac, Omar M ; Jayyousi, Amin ; Al Suwaidi, Jassim ; Crystal, Ronald G ; Atkin, Stephen L ; Abi Khalil, Charbel</creatorcontrib><description>Vitamin D measurement is a composite of vitamin D
(25(OH)D
) and D
(25(OH)D
) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D
supplements. This study was undertaken to determine if vitamin D
and D
levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D
and vitamin D
levels in subjects with T2DM
METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D
and D
were measured by LC-MS/MS analysis.
All subjects were taking vitamin D
and none were taking D
supplements. Vitamin D
levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D
levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D
nor vitamin D
were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D
and vitamin D
showed no difference.
In this Qatari cohort, vitamin D
was associated with hypertension and dyslipidemia, whilst vitamin D
levels were associated with diabetic retinopathy. Vitamin D
levels were higher, whilst vitamin D
were lower in diabetics and females, likely due to ingestion of vitamin D
supplements.</description><identifier>EISSN: 1472-6823</identifier><identifier>PMID: 32414363</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Blood Glucose - drug effects ; Blood Glucose - metabolism ; Cholecalciferol - blood ; Cohort Studies ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; Dietary Supplements ; Ergocalciferols - administration & dosage ; Ergocalciferols - blood ; Female ; Humans ; Male ; Middle Aged ; Qatar - epidemiology ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - drug therapy ; Vitamin D Deficiency - epidemiology</subject><ispartof>BMC endocrine disorders, 2020-05, Vol.20 (1), p.65</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5762-3917</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32414363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Lina H M</creatorcontrib><creatorcontrib>Butler, Alexandra E</creatorcontrib><creatorcontrib>Dargham, Soha R</creatorcontrib><creatorcontrib>Latif, Aishah</creatorcontrib><creatorcontrib>Robay, Amal</creatorcontrib><creatorcontrib>Chidiac, Omar M</creatorcontrib><creatorcontrib>Jayyousi, Amin</creatorcontrib><creatorcontrib>Al Suwaidi, Jassim</creatorcontrib><creatorcontrib>Crystal, Ronald G</creatorcontrib><creatorcontrib>Atkin, Stephen L</creatorcontrib><creatorcontrib>Abi Khalil, Charbel</creatorcontrib><title>Association of vitamin D 2 and D 3 with type 2 diabetes complications</title><title>BMC endocrine disorders</title><addtitle>BMC Endocr Disord</addtitle><description>Vitamin D measurement is a composite of vitamin D
(25(OH)D
) and D
(25(OH)D
) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D
supplements. This study was undertaken to determine if vitamin D
and D
levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D
and vitamin D
levels in subjects with T2DM
METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D
and D
were measured by LC-MS/MS analysis.
All subjects were taking vitamin D
and none were taking D
supplements. Vitamin D
levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D
levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D
nor vitamin D
were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D
and vitamin D
showed no difference.
In this Qatari cohort, vitamin D
was associated with hypertension and dyslipidemia, whilst vitamin D
levels were associated with diabetic retinopathy. Vitamin D
levels were higher, whilst vitamin D
were lower in diabetics and females, likely due to ingestion of vitamin D
supplements.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Glucose - drug effects</subject><subject>Blood Glucose - metabolism</subject><subject>Cholecalciferol - blood</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Dietary Supplements</subject><subject>Ergocalciferols - administration & dosage</subject><subject>Ergocalciferols - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Qatar - epidemiology</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - drug therapy</subject><subject>Vitamin D Deficiency - epidemiology</subject><issn>1472-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFjdsKgkAURYcg0i6_EOcHBJ0Z1Ncoow_oXUYd6YRzwTMV_n0S9dzTgs3arAWLM1nwJC-5iNia6J6mWVHydMUiwWUmRS5iVh2IXIsqoLPgenhiUAYtnICDst1MAS8MNwiT1_PWoWp00AStM37A9nOkLVv2aiC9-3LD9ufqerwk_tEY3dV-RKPGqf51xV_hDTKWNrY</recordid><startdate>20200515</startdate><enddate>20200515</enddate><creator>Ahmed, Lina H M</creator><creator>Butler, Alexandra E</creator><creator>Dargham, Soha R</creator><creator>Latif, Aishah</creator><creator>Robay, Amal</creator><creator>Chidiac, Omar M</creator><creator>Jayyousi, Amin</creator><creator>Al Suwaidi, Jassim</creator><creator>Crystal, Ronald G</creator><creator>Atkin, Stephen L</creator><creator>Abi Khalil, Charbel</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><orcidid>https://orcid.org/0000-0002-5762-3917</orcidid></search><sort><creationdate>20200515</creationdate><title>Association of vitamin D 2 and D 3 with type 2 diabetes complications</title><author>Ahmed, Lina H M ; Butler, Alexandra E ; Dargham, Soha R ; Latif, Aishah ; Robay, Amal ; Chidiac, Omar M ; Jayyousi, Amin ; Al Suwaidi, Jassim ; Crystal, Ronald G ; Atkin, Stephen L ; Abi Khalil, Charbel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_324143633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Glucose - drug effects</topic><topic>Blood Glucose - metabolism</topic><topic>Cholecalciferol - blood</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Dietary Supplements</topic><topic>Ergocalciferols - administration & dosage</topic><topic>Ergocalciferols - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Qatar - epidemiology</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - drug therapy</topic><topic>Vitamin D Deficiency - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Lina H M</creatorcontrib><creatorcontrib>Butler, Alexandra E</creatorcontrib><creatorcontrib>Dargham, Soha R</creatorcontrib><creatorcontrib>Latif, Aishah</creatorcontrib><creatorcontrib>Robay, Amal</creatorcontrib><creatorcontrib>Chidiac, Omar M</creatorcontrib><creatorcontrib>Jayyousi, Amin</creatorcontrib><creatorcontrib>Al Suwaidi, Jassim</creatorcontrib><creatorcontrib>Crystal, Ronald G</creatorcontrib><creatorcontrib>Atkin, Stephen L</creatorcontrib><creatorcontrib>Abi Khalil, Charbel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>BMC endocrine disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Lina H M</au><au>Butler, Alexandra E</au><au>Dargham, Soha R</au><au>Latif, Aishah</au><au>Robay, Amal</au><au>Chidiac, Omar M</au><au>Jayyousi, Amin</au><au>Al Suwaidi, Jassim</au><au>Crystal, Ronald G</au><au>Atkin, Stephen L</au><au>Abi Khalil, Charbel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of vitamin D 2 and D 3 with type 2 diabetes complications</atitle><jtitle>BMC endocrine disorders</jtitle><addtitle>BMC Endocr Disord</addtitle><date>2020-05-15</date><risdate>2020</risdate><volume>20</volume><issue>1</issue><spage>65</spage><pages>65-</pages><eissn>1472-6823</eissn><abstract>Vitamin D measurement is a composite of vitamin D
(25(OH)D
) and D
(25(OH)D
) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D
supplements. This study was undertaken to determine if vitamin D
and D
levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D
and vitamin D
levels in subjects with T2DM
METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D
and D
were measured by LC-MS/MS analysis.
All subjects were taking vitamin D
and none were taking D
supplements. Vitamin D
levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D
levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D
nor vitamin D
were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D
and vitamin D
showed no difference.
In this Qatari cohort, vitamin D
was associated with hypertension and dyslipidemia, whilst vitamin D
levels were associated with diabetic retinopathy. Vitamin D
levels were higher, whilst vitamin D
were lower in diabetics and females, likely due to ingestion of vitamin D
supplements.</abstract><cop>England</cop><pmid>32414363</pmid><orcidid>https://orcid.org/0000-0002-5762-3917</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1472-6823 |
| ispartof | BMC endocrine disorders, 2020-05, Vol.20 (1), p.65 |
| issn | 1472-6823 |
| language | eng |
| recordid | cdi_pubmed_primary_32414363 |
| source | ProQuest - Publicly Available Content Database; PubMed Central |
| subjects | Adult Aged Blood Glucose - drug effects Blood Glucose - metabolism Cholecalciferol - blood Cohort Studies Cross-Sectional Studies Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Dietary Supplements Ergocalciferols - administration & dosage Ergocalciferols - blood Female Humans Male Middle Aged Qatar - epidemiology Vitamin D Deficiency - blood Vitamin D Deficiency - drug therapy Vitamin D Deficiency - epidemiology |
| title | Association of vitamin D 2 and D 3 with type 2 diabetes complications |
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