DHA Affects Microtubule Dynamics Through Reduction of Phospho-TCTP Levels and Enhances the Antiproliferative Effect of T-DM1 in Trastuzumab-Resistant HER2-Positive Breast Cancer Cell Lines

Trastuzumab emtansine (T-DM1) is an anti-human epidermal growth factor receptor 2 (HER2) antibody-drug conjugated to the microtubule-targeting agent emtansine (DM1). T-DM1 is an effective agent in the treatment of patients with HER2-positive breast cancer whose disease has progressed on the first-li...

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Published in:	Cells (Basel, Switzerland) Switzerland), 2020-05, Vol.9 (5), p.1260
Main Authors:	D’Amico, Silvia, Krasnowska, Ewa, Manni, Isabella, Toietta, Gabriele, Baldari, Silvia, Piaggio, Giulia, Ranalli, Marco, Gambacurta, Alessandra, Vernieri, Claudio, Di Giacinto, Flavio, Bernassola, Francesca, de Braud, Filippo, Lucibello, Maria
Format:	Article
Language:	English
Subjects:	Animals Antibodies Apoptosis - drug effects Artemisinins - pharmacology Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Cell cycle Cell growth Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cytotoxicity DHA Dihydroartemisinin DNA Damage Drug Resistance, Neoplasm Epidermal growth factor Epithelial cells ErbB-2 protein Female HER2-positive breast cancer Humans Immunotherapy Kinases Mammary gland Medical prognosis Mice, SCID Microtubules Microtubules - drug effects Microtubules - metabolism Mitosis Mitosis - drug effects Monoclonal antibodies Oxidative Stress - drug effects Phosphatidylinositol 3-Kinases - metabolism phospho-TCTP Phosphorylation Phosphorylation - drug effects Proteins Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species - metabolism Receptor, ErbB-2 - metabolism Signal Transduction - drug effects T-DM1 Targeted cancer therapy Trastuzumab Trastuzumab - pharmacology Trastuzumab - therapeutic use Tumor cell lines Tumors Xenografts
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