A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

Since December 2019, a novel coronavirus SARS-CoV-2 has emerged and rapidly spread throughout the world, resulting in a global public health emergency. The lack of vaccine and antivirals has brought an urgent need for an animal model. Human angiotensin-converting enzyme II (ACE2) has been identified...

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Bibliographic Details
Published in:	Cell Host & Microbe 2020-07, Vol.28 (1), p.124-133.e4
Main Authors:	Sun, Shi-Hui, Chen, Qi, Gu, Hong-Jing, Yang, Guan, Wang, Yan-Xiao, Huang, Xing-Yao, Liu, Su-Su, Zhang, Na-Na, Li, Xiao-Feng, Xiong, Rui, Guo, Yan, Deng, Yong-Qiang, Huang, Wei-Jin, Liu, Quan, Liu, Quan-Ming, Shen, Yue-Lei, Zhou, Yong, Yang, Xiao, Zhao, Tong-Yan, Fan, Chang-Fa, Zhou, Yu-Sen, Qin, Cheng-Feng, Wang, You-Chun
Format:	Article
Language:	English
Subjects:	Aging Angiotensin-Converting Enzyme 2 angiotensin-converting enzyme II Animals Betacoronavirus - physiology Brain - virology Coronavirus Infections - pathology Coronavirus Infections - virology COVID-19 CRISPR-Cas Systems Cytokines - blood Disease Models, Animal Gene Knock-In Techniques hACE2-KI/NIFDC Lung - pathology Lung - virology Lung Diseases, Interstitial - pathology Mice, Inbred C57BL mouse model Nose - virology Pandemics pathogenesis Peptidyl-Dipeptidase A - genetics Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - pathology Pneumonia, Viral - virology RNA, Viral - analysis SARS-CoV-2 Stomach - virology Trachea - virology Viral Load Virus Replication
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