The effect of cardiorespiratory fitness and physical activity levels on cognitive functions in survivors of childhood acute lymphoblastic leukemia

Introduction. Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase co...

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Published in:Pediatric hematology and oncology 2020-10, Vol.37 (7), p.582-598
Main Authors: Gendron, Élisabelle, Caru, Maxime, Léveillé, Pauline, Sultan, Serge, Robaey, Philippe, Lemay, Valérie, Drouin, Simon, Bertout, Laurence, Andelfinger, Gregor, Krajinovic, Maja, Laverdière, Caroline, Sinnett, Daniel, Lippé, Sarah, Curnier, Daniel
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Adult
Cancer Survivors
Cardiorespiratory Fitness
Child
Cognition
cognitive function
Exercise
Female
Humans
Male
Neuropsychological Tests
Odds Ratio
physical activity
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - physiopathology
preventive fraction
Surveys and Questionnaires
Young Adult
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Summary:Introduction. Most childhood acute lymphoblastic leukemia (ALL) survivors develop chronic treatment-related adverse effects several years after the end of the treatment. Regular physical activity and a good cardiorespiratory fitness can decrease the risks of neurological disturbances and increase cognitive function scores. The aim of this study was to examine the effect of good cardiorespiratory fitness and physical activity levels on cognitive functions. Methods. We enrolled 219 survivors of childhood ALL. The participants underwent a cardiopulmonary exercise test, neuropsychological tests of executive functions (i.e. verbal fluency, cognitive flexibility, working memory, processing speed) and completed a physical activity questionnaire. We calculated the odds ratio to obtain the preventive fraction of physical activity and cardiorespiratory fitness levels on cognitive functions. Results. The cohort is 52% male and 48% female. A total of 182 survivors (83%) have a cardiorespiratory fitness below their predicted (
ISSN:0888-0018
1521-0669
DOI:10.1080/08880018.2020.1767737