Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies

Antibodies targeting the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present a promising approach to combat the coronavirus disease 2019 (COVID-19) pandemic; however, concerns remain that mutations can yield antibody resistance. We investigated the development of re...

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Bibliographic Details
Published in:Science 2020-08, Vol.369 (6506), p.1014-1018
Main Authors: Baum, Alina, Fulton, Benjamin O., Wloga, Elzbieta, Copin, Richard, Pascal, Kristen E., Russo, Vincenzo, Giordano, Stephanie, Lanza, Kathryn, Negron, Nicole, Ni, Min, Wei, Yi, Atwal, Gurinder S., Murphy, Andrew J., Stahl, Neil, Yancopoulos, George D., Kyratsous, Christos A.
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Neutralizing - immunology
Antibodies, Viral - immunology
Betacoronavirus - chemistry
Betacoronavirus - genetics
Betacoronavirus - immunology
Binding
Coronaviridae
Coronavirus Infections - immunology
Coronaviruses
COVID-19
Epitopes
Genome, Viral
Human populations
Humans
Mutant Proteins - chemistry
Mutant Proteins - immunology
Mutants
Mutation
Neutralization
Neutralization Tests
Pandemics
Pneumonia, Viral - immunology
Protein Interaction Domains and Motifs
Proteins
Respiratory diseases
SARS-CoV-2
Selection, Genetic
Severe acute respiratory syndrome coronavirus 2
Spike Glycoprotein, Coronavirus - chemistry
Spike Glycoprotein, Coronavirus - genetics
Spike Glycoprotein, Coronavirus - immunology
Spike protein
Viral diseases
Virology
Viruses
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