Klotho overexpression improves amyloid‐β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease

Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the presence of amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels in the brain and protected against cognitive deficits in amyloid precursor protein/presenilin 1(APP/PS1) mice. However,...

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Bibliographic Details
Published in:Aging cell 2020-10, Vol.19 (10), p.e13239-n/a
Main Authors: Zhao, Yue, Zeng, Chen‐Ye, Li, Xiao‐Hong, Yang, Ting‐Ting, Kuang, Xi, Du, Jun‐Rong
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer's disease
Amyloid precursor protein
Aβ clearance
Brain
Cerebrospinal fluid
Choroid plexus
Cognition & reasoning
Cognitive ability
Dementia disorders
Epithelial cells
Hypotheses
Klotho
Klotho protein
Microglia
Neurodegenerative diseases
Neurons
Neuroprotection
Original
Pathogenesis
Peptides
Presenilin 1
Proteins
Senile plaques
Statistical analysis
Target marketing
Variance analysis
Ventricle
Ventricles (cerebral)
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