Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway

Background The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). Methods Serum from patients with RA and osteoarthritis (OA), and healthy...

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Bibliographic Details
Published in:Arthritis research & therapy 2020-09, Vol.22 (1), p.222-11, Article 222
Main Authors: Min, Hong Ki, Won, Ji-Yeon, Kim, Bo-Mi, Lee, Kyung-Ann, Lee, Seoung-Joon, Lee, Sang-Heon, Kim, Hae-Rim, Kim, Kyoung-Woon
Format: Article
Language:English
Subjects:
Antibodies
Arthritis
Arthritis, Rheumatoid
Cartilage
Cells, Cultured
Cytokines
Fibroblasts - metabolism
Humans
IL-22
IL-25
Interleukin-17
Interleukin-22
Interleukins - metabolism
Joint replacement surgery
Medicine
Medicine & Public Health
NF-KappaB Inhibitor alpha
Orthopedics
Osteoclastogenesis
Osteoclasts - metabolism
Osteogenesis
p38 Mitogen-Activated Protein Kinases
RANK Ligand - metabolism
Research Article
Rheumatoid arthritis
Rheumatology
STAT3 Transcription Factor
Statistical analysis
Synovial Membrane - metabolism
Tumor necrosis factor-TNF
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