Melatonin attenuates diabetic cardiomyopathy and reduces myocardial vulnerability to ischemia‐reperfusion injury by improving mitochondrial quality control: Role of SIRT6

Targeting mitochondrial quality control with melatonin has been found promising for attenuating diabetic cardiomyopathy (DCM), although the underlying mechanisms remain largely undefined. Activation of SIRT6 and melatonin membrane receptors exerts cardioprotective effects while little is known about...

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Bibliographic Details
Published in:	Journal of pineal research 2021-01, Vol.70 (1), p.e12698-n/a
Main Authors:	Yu, Li‐Ming, Dong, Xue, Xue, Xiao‐Dong, Xu, Shu, Zhang, Xu, Xu, Yin‐Li, Wang, Zhi‐Shang, Wang, Yang, Gao, Hao, Liang, Yan‐Xiao, Yang, Yang, Wang, Hui‐Shan
Format:	Article
Language:	English
Subjects:	AMP-Activated Protein Kinases - metabolism Animals Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Type 2 - complications Diabetic Cardiomyopathies - enzymology Diabetic Cardiomyopathies - etiology Diabetic Cardiomyopathies - pathology Diabetic Cardiomyopathies - prevention & control diabetic cardiomyopathy Forkhead Box Protein O3 - metabolism Male Melatonin - pharmacology melatonin membrane receptors Mitochondria, Heart - drug effects Mitochondria, Heart - enzymology Mitochondria, Heart - ultrastructure mitochondrial quality control myocardial ischemia‐reperfusion Myocardial Reperfusion Injury - enzymology Myocardial Reperfusion Injury - pathology Myocardial Reperfusion Injury - prevention & control Myocytes, Cardiac - drug effects Myocytes, Cardiac - enzymology Myocytes, Cardiac - ultrastructure Organelle Biogenesis Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - metabolism Proto-Oncogene Proteins c-akt - metabolism Rats Rats, Sprague-Dawley Signal Transduction SIRT6 Sirtuins - genetics Sirtuins - metabolism Time Factors
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