Relationship of IGF-1 and IGF-Binding Proteins to Disease Severity and Glycemia in Nonalcoholic Fatty Liver Disease

Abstract Context Growth hormone (GH) and IGF-1 help regulate hepatic glucose and lipid metabolism, and reductions in these hormones may contribute to development of nonalcoholic fatty liver disease (NAFLD). Objective To assess relationships between hepatic expression of IGF1 and IGF-binding proteins...

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Published in:	The journal of clinical endocrinology and metabolism 2021-02, Vol.106 (2), p.e520-e533
Main Authors:	Stanley, Takara L, Fourman, Lindsay T, Zheng, Isabel, McClure, Colin M, Feldpausch, Meghan N, Torriani, Martin, Corey, Kathleen E, Chung, Raymond T, Lee, Hang, Kleiner, David E, Hadigan, Colleen M, Grinspoon, Steven K
Format:	Article
Language:	English
Subjects:	Adult Binding proteins Biopsy Blood glucose Blood Glucose - metabolism Clinical s Dextrose Double-Blind Method Fatty liver Female Fibrosis Follow-Up Studies Glucose Glucose metabolism Gonadotropin-Releasing Hormone - analogs & derivatives Growth hormone-releasing hormone Growth Hormone-Releasing Hormone - analogs & derivatives Growth Hormone-Releasing Hormone - therapeutic use Growth hormones HIV HIV (Viruses) HIV Infections - blood HIV Infections - complications HIV Infections - drug therapy HIV Infections - metabolism Homeostasis Human immunodeficiency virus Humans Insulin resistance Insulin-Like Growth Factor Binding Proteins - blood Insulin-Like Growth Factor Binding Proteins - genetics Insulin-like growth factor I Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factor-binding protein 1 Insulin-like growth factor-binding protein 2 Insulin-like growth factor-binding protein 3 Insulin-like growth factor-binding protein 4 Insulin-like growth factor-binding protein 6 Insulin-like growth factors Lipid metabolism Liver diseases Male Medical colleges Middle Aged mRNA Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - drug therapy Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology Physiological aspects Protein binding RNA RNA sequencing Severity of Illness Index Somatotropin Steatosis Tesamorelin
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