microRNA-322/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2/HIF-1α pathway

To investigate the effects and mechanism of miR-322/424 in liver fibrosis. miR-322/424 expression in liver cirrhosis patients, mouse and rat liver fibrosis was determined by qPCR. Mice liver fibrosis was established by CCl4, and intervened by miR-322/424 agomir or antagomir. Liver hydroxyproline con...

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Bibliographic Details
Published in:	Life sciences (1973) 2021-02, Vol.266, p.118819, Article 118819
Main Authors:	Wang, Qinglan, Zhang, Feng, Lei, Yang, Liu, Ping, Liu, Chenghai, Tao, Yanyan
Format:	Article
Language:	English
Subjects:	Angiogenesis Animals Bile bioluminescence assay blood coagulation factors Carbon tetrachloride Cell migration cell movement Cells, Cultured Cirrhosis Collagen Cullin Proteins - genetics Cullin Proteins - metabolism Disease Models, Animal Endothelial cells Fibrosis Gene expression Hemangioma - genetics Hemangioma - metabolism Hemangioma - pathology Hepatic angiogenesis Humans Hydroxyproline Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Inhibitors Liver Liver cirrhosis Liver Cirrhosis - genetics Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver fibrosis luciferase Male Mice Mice, Inbred C57BL Mice, Inbred ICR microRNA MicroRNAs - genetics microvessels miR-322/424 miRNA N-Nitrosodimethylamine Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology Pathogenesis Protein expression protein synthesis Proteins Rats Rats, Wistar Ribonucleic acid RNA Von Willebrand factor Western blotting
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