A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia

Impaired DNA crosslink repair leads to Fanconi anemia (FA), characterized by a unique manifestation of bone marrow failure and pancytopenia among diseases caused by DNA damage response defects. As a germline disorder, why the hematopoietic hierarchy is specifically affected is not fully understood....

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Bibliographic Details
Published in:	Molecular cell 2020-12, Vol.80 (6), p.1013-1024.e6
Main Authors:	Shen, Xi, Wang, Rui, Kim, Moon Jong, Hu, Qianghua, Hsu, Chih-Chao, Yao, Jun, Klages-Mundt, Naeh, Tian, Yanyan, Lynn, Erica, Brewer, Thomas F., Zhang, Yilei, Arun, Banu, Gan, Boyi, Andreeff, Michael, Takeda, Shunichi, Chen, Junjie, Park, Jae-il, Shi, Xiaobing, Chang, Christopher J., Jung, Sung Yun, Qin, Jun, Li, Lei
Format:	Article
Language:	English
Subjects:	bone marrow bone marrow failure byproducts Cell Differentiation - drug effects cell viability Cellular Reprogramming - genetics demethylation differentiation DNA damage DNA Damage - drug effects DNA repair DNA Repair - genetics Fanconi anemia Fanconi Anemia - blood Fanconi Anemia - genetics Fanconi Anemia - pathology formaldehyde Formaldehyde - metabolism Formaldehyde - toxicity Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics genome Genomic Instability - genetics germ cells hematopoiesis Hematopoietic Stem Cell Transplantation Hematopoietic Stem Cells - drug effects Humans K562 Cells mutagens mutants transcription (genetics) transcription reprogramming Transcription, Genetic
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