New phenolics from Uraria crinita (L.) DC

Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranosi...

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Published in:Natural product research 2022-07, Vol.36 (13), p.3381-3388
Main Authors: Thien, Dao Duc, Tai, Bui Huu, Dai, Tran Duc, Sa, Nguyen Hoang, Thuy, Trinh Thi, Hoang Anh, Nguyen Thi, Tam, Nguyen Thanh
Format: Article
Language:English
Subjects:
Cell lines
Cytotoxicity
Glucosides
isoflavanone
monoaryl glucosides
NMR
Nuclear magnetic resonance
phenolics
Phenols
Uraria crinita
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cited_by cdi_FETCH-LOGICAL-c394t-ff2509f243d689e1717fd33b6b47a988d23595377a50267465364515537752053
cites cdi_FETCH-LOGICAL-c394t-ff2509f243d689e1717fd33b6b47a988d23595377a50267465364515537752053
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container_title Natural product research
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description Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6′-O-acetyl)-β-D-glucopyranoside (3), in addition to three known compounds, 3′-O-methylorobol (4), robusflavone B (5), and apigenin (6). The structural elucidation of these compounds was achieved by analyses of their spectroscopic data (HR-ESI-MS, 1 D- and 2 D-NMR) and acidic hydrolysis. The U. crinita extracts and compounds 1-6 exhibited weak or no cytotoxic activity against KB, HepG2, Lu and MCF7 cell lines.
doi_str_mv 10.1080/14786419.2020.1860973
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source Taylor and Francis Science and Technology Collection
subjects Cell lines
Cytotoxicity
Glucosides
isoflavanone
monoaryl glucosides
NMR
Nuclear magnetic resonance
phenolics
Phenols
Uraria crinita
title New phenolics from Uraria crinita (L.) DC
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