MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma

The histone acetyltransferase MOF (KAT8) is mainly involved in the acetylation of histone H4 at lysine 16 (H4K16) and some non‐histone proteins. The MOF expression level is significantly reduced in many cancers, however the biological function of MOF and its underlying mechanism are still elusive in...

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Bibliographic Details
Published in:	Cancer science 2021-05, Vol.112 (5), p.1865-1877
Main Authors:	Wei, Shan, Liu, Wei, Sun, Ning, Wu, Yi, Song, Huijuan, Wang, Chunyu, Wang, Shengli, Zou, Renlong, Lin, Lin, Zeng, Kai, Zhou, Baosheng, Wang, Manlin, Luan, Ruina, Yang, Fan, Zhao, Yue
Format:	Article
Language:	English
Subjects:	Acetylation Acetylesterase - metabolism Animals Antibodies - therapeutic use Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell growth Cell migration Cell Movement Cell Proliferation Cloning Databases, Genetic Datasets Down-Regulation Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism estrogen receptor α Estrogen receptors Estrogens Female Gene expression Hepatocellular carcinoma Heterografts Histone acetyltransferase Histone Acetyltransferases - deficiency Histone Acetyltransferases - metabolism Histone H4 Histones - metabolism Humans Infections Kaplan-Meier Estimate Liver cancer Liver Neoplasms - enzymology Liver Neoplasms - metabolism Liver Neoplasms - mortality Liver Neoplasms - pathology Lysine Lysine - metabolism Male Medical prognosis Mice Middle Aged MOF Neoplasm Invasiveness Original Protein expression Proteins Signal Transduction Statistical analysis Transcriptional Activation tumor suppression Tumor suppressor genes Ubiquitination Up-Regulation
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