Clump sequencing exposes the spatial expression programs of intestinal secretory cells

Single-cell RNA sequencing combined with spatial information on landmark genes enables reconstruction of spatially-resolved tissue cell atlases. However, such approaches are challenging for rare cell types, since their mRNA contents are diluted in the spatial transcriptomics bulk measurements used f...

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Bibliographic Details
Published in:	Nature communications 2021-05, Vol.12 (1), p.3074-13, Article 3074
Main Authors:	Manco, Rita, Averbukh, Inna, Porat, Ziv, Bahar Halpern, Keren, Amit, Ido, Itzkovitz, Shalev
Format:	Article
Language:	English
Subjects:	13 13/31 38/91 45 631/114 631/136/142 631/1647/514/1949 631/553/2706 631/80 Animals Biological Transport - genetics Biological Transport - physiology Cell Differentiation Cell migration Clumps Computational Biology - methods Enterocytes Enterocytes - metabolism Enteroendocrine Cells - metabolism Epithelial cells Epithelial Cells - metabolism Epithelium Gene Expression Gene sequencing Genes Humanities and Social Sciences Immunomodulation Intestinal Mucosa - metabolism Intestine Intestine, Small - metabolism Intestines - physiology Mice Mice, Inbred C57BL multidisciplinary Reconstruction RNA, Messenger - metabolism Science Science (multidisciplinary) Sequence Analysis, RNA Small intestine Spatial data Transcriptomics Tumors Villus Zonation
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