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The Type VII Secretion System of Staphylococcus
The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the ess locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across S. aureus strains, each accompanied by...
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| Published in: | Annual review of microbiology 2021-10, Vol.75 (1), p.471-494 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-a406t-1866b2f2ebe716a58547360d439888a6a2bfecef2b427a2f82da161fc93b21853 |
| container_end_page | 494 |
| container_issue | 1 |
| container_start_page | 471 |
| container_title | Annual review of microbiology |
| container_volume | 75 |
| creator | Bowman, Lisa Palmer, Tracy |
| description | The type VII protein secretion system (T7SS) of
Staphylococcus aureus
is encoded at the
ess
locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across
S. aureus
strains, each accompanied by a specific suite of substrate proteins. The
ess
genes are upregulated during persistent infection, and the secretion system contributes to virulence in disease models. It also plays a key role in intraspecies competition, secreting nuclease and membrane-depolarizing toxins that inhibit the growth of strains lacking neutralizing immunity proteins. A genomic survey indicates that the T7SS is widely conserved across staphylococci and is encoded in clusters that contain diverse arrays of toxin and immunity genes. The presence of genomic islands encoding multiple immunity proteins in species such as
Staphylococcus warneri
that lack the T7SS points to a major role for the secretion system in bacterial antagonism. |
| doi_str_mv | 10.1146/annurev-micro-012721-123600 |
| format | article |
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Staphylococcus aureus
is encoded at the
ess
locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across
S. aureus
strains, each accompanied by a specific suite of substrate proteins. The
ess
genes are upregulated during persistent infection, and the secretion system contributes to virulence in disease models. It also plays a key role in intraspecies competition, secreting nuclease and membrane-depolarizing toxins that inhibit the growth of strains lacking neutralizing immunity proteins. A genomic survey indicates that the T7SS is widely conserved across staphylococci and is encoded in clusters that contain diverse arrays of toxin and immunity genes. The presence of genomic islands encoding multiple immunity proteins in species such as
Staphylococcus warneri
that lack the T7SS points to a major role for the secretion system in bacterial antagonism.</description><identifier>ISSN: 0066-4227</identifier><identifier>EISSN: 1545-3251</identifier><identifier>DOI: 10.1146/annurev-micro-012721-123600</identifier><identifier>PMID: 34343022</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>Adenosine triphosphatase ; Antagonism ; bacterial antagonism ; Depolarization ; Genes ; Genomic islands ; Genomics ; Immunity ; Membranes ; Nuclease ; protein secretion ; Protein transport ; Proteins ; Staphylococcus ; Strains (organisms) ; Substrates ; T7SS ; Toxins ; Virulence</subject><ispartof>Annual review of microbiology, 2021-10, Vol.75 (1), p.471-494</ispartof><rights>Copyright Annual Reviews, Inc. 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a406t-1866b2f2ebe716a58547360d439888a6a2bfecef2b427a2f82da161fc93b21853</citedby><cites>FETCH-LOGICAL-a406t-1866b2f2ebe716a58547360d439888a6a2bfecef2b427a2f82da161fc93b21853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-micro-012721-123600?crawler=true&mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-micro-012721-123600$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,780,784,4182,27924,27925,78254,78255</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34343022$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowman, Lisa</creatorcontrib><creatorcontrib>Palmer, Tracy</creatorcontrib><title>The Type VII Secretion System of Staphylococcus</title><title>Annual review of microbiology</title><addtitle>Annu Rev Microbiol</addtitle><description>The type VII protein secretion system (T7SS) of
Staphylococcus aureus
is encoded at the
ess
locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across
S. aureus
strains, each accompanied by a specific suite of substrate proteins. The
ess
genes are upregulated during persistent infection, and the secretion system contributes to virulence in disease models. It also plays a key role in intraspecies competition, secreting nuclease and membrane-depolarizing toxins that inhibit the growth of strains lacking neutralizing immunity proteins. A genomic survey indicates that the T7SS is widely conserved across staphylococci and is encoded in clusters that contain diverse arrays of toxin and immunity genes. The presence of genomic islands encoding multiple immunity proteins in species such as
Staphylococcus warneri
that lack the T7SS points to a major role for the secretion system in bacterial antagonism.</description><subject>Adenosine triphosphatase</subject><subject>Antagonism</subject><subject>bacterial antagonism</subject><subject>Depolarization</subject><subject>Genes</subject><subject>Genomic islands</subject><subject>Genomics</subject><subject>Immunity</subject><subject>Membranes</subject><subject>Nuclease</subject><subject>protein secretion</subject><subject>Protein transport</subject><subject>Proteins</subject><subject>Staphylococcus</subject><subject>Strains (organisms)</subject><subject>Substrates</subject><subject>T7SS</subject><subject>Toxins</subject><subject>Virulence</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNqVkD1PwzAQhi0EoqXwF1CkLiym9sV2HLGAKj4qITG0sFpOelFT5aPECSj_HpcUBjZ0wy3P-97pIWTK2TXnQs1sVXUNftAyT5uaMg4RcMohVIwdkTGXQtIQJD8mY8aUogIgGpEz57aMMRGx-JSMQuGHAYzJbLXBYNXvMHhbLIIlpg22eV0Fy961WAZ1Fixbu9v0RZ3Wadq5c3KS2cLhxWFPyOvD_Wr-RJ9fHhfzu2dqBVMt5VqpBDLABCOurNRSRP7BtQhjrbVVFpIMU8wgERBZyDSsLVc8S-MwAa5lOCFXQ--uqd87dK0pc5diUdgK684ZkFKzGELgHp3-Qbd111T-O0_FkeQgdOipm4Hy0pxrMDO7Ji9t0xvOzN6rOXg1317N4NUMXn368nCjS0pc_2Z_RHrgdgD2LbbwPTl-un_d-AJLVoty</recordid><startdate>20211008</startdate><enddate>20211008</enddate><creator>Bowman, Lisa</creator><creator>Palmer, Tracy</creator><general>Annual Reviews</general><general>Annual Reviews, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20211008</creationdate><title>The Type VII Secretion System of Staphylococcus</title><author>Bowman, Lisa ; Palmer, Tracy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a406t-1866b2f2ebe716a58547360d439888a6a2bfecef2b427a2f82da161fc93b21853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adenosine triphosphatase</topic><topic>Antagonism</topic><topic>bacterial antagonism</topic><topic>Depolarization</topic><topic>Genes</topic><topic>Genomic islands</topic><topic>Genomics</topic><topic>Immunity</topic><topic>Membranes</topic><topic>Nuclease</topic><topic>protein secretion</topic><topic>Protein transport</topic><topic>Proteins</topic><topic>Staphylococcus</topic><topic>Strains (organisms)</topic><topic>Substrates</topic><topic>T7SS</topic><topic>Toxins</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowman, Lisa</creatorcontrib><creatorcontrib>Palmer, Tracy</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowman, Lisa</au><au>Palmer, Tracy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Type VII Secretion System of Staphylococcus</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>2021-10-08</date><risdate>2021</risdate><volume>75</volume><issue>1</issue><spage>471</spage><epage>494</epage><pages>471-494</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><abstract>The type VII protein secretion system (T7SS) of
Staphylococcus aureus
is encoded at the
ess
locus. T7 substrate recognition and protein transport are mediated by EssC, a membrane-bound multidomain ATPase. Four EssC sequence variants have been identified across
S. aureus
strains, each accompanied by a specific suite of substrate proteins. The
ess
genes are upregulated during persistent infection, and the secretion system contributes to virulence in disease models. It also plays a key role in intraspecies competition, secreting nuclease and membrane-depolarizing toxins that inhibit the growth of strains lacking neutralizing immunity proteins. A genomic survey indicates that the T7SS is widely conserved across staphylococci and is encoded in clusters that contain diverse arrays of toxin and immunity genes. The presence of genomic islands encoding multiple immunity proteins in species such as
Staphylococcus warneri
that lack the T7SS points to a major role for the secretion system in bacterial antagonism.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>34343022</pmid><doi>10.1146/annurev-micro-012721-123600</doi><tpages>24</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4227 |
| ispartof | Annual review of microbiology, 2021-10, Vol.75 (1), p.471-494 |
| issn | 0066-4227 1545-3251 |
| language | eng |
| recordid | cdi_pubmed_primary_34343022 |
| source | Annual Reviews |
| subjects | Adenosine triphosphatase Antagonism bacterial antagonism Depolarization Genes Genomic islands Genomics Immunity Membranes Nuclease protein secretion Protein transport Proteins Staphylococcus Strains (organisms) Substrates T7SS Toxins Virulence |
| title | The Type VII Secretion System of Staphylococcus |
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