Physiological characterization of an arginine vasopressin rat model of preeclampsia

Rodent models have contributed greatly to our understanding of preeclampsia (PE) progression in humans, however to-date no model has been able to effectively replicate the clinical presentation of the disease. This study aimed to provide a thorough physiological characterization of the arginine vaso...

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Published in:Systems biology in reproductive medicine 2022-01, Vol.68 (1), p.55-69
Main Authors: Ramdin, Sapna, Naicker, Thajasvarie, Pillay, Virushka, Singh, Sanil D., Baijnath, Sooraj, Mkhwanazi, Blessing N, Govender, Nalini
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin
blood pressure
Female
Placenta
Placenta Growth Factor
Pre-Eclampsia - chemically induced
preeclampsia
Pregnancy
proteinuria
Rats
Rats, Sprague-Dawley
Vascular Endothelial Growth Factor A
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Summary:Rodent models have contributed greatly to our understanding of preeclampsia (PE) progression in humans, however to-date no model has been able to effectively replicate the clinical presentation of the disease. This study aimed to provide a thorough physiological characterization of the arginine vasopressin (AVP)-induced rat model of PE to determine its applicability in studying the pathophysiology of PE. Female Sprague Dawley rats (n = 24) were separated into four groups (n = 6 per group) viz., pregnant AVP, pregnant saline, non-pregnant AVP, and non-pregnant saline. All animals received a continuous dose of either AVP (150 ng/h) or saline via subcutaneous mini osmotic pumps for 18 days. Full physiological characterization of the model included measuring systolic and diastolic blood pressure, and collecting urine and blood samples for biochemical analysis. AVP infusion significantly increased blood pressure and urinary protein levels in the pregnant rats (p
ISSN:1939-6368
1939-6376
DOI:10.1080/19396368.2021.1981486