Glyco‐Steroidal Amphiphiles (GSAs) for Membrane Protein Structural Study

Integral membrane proteins pose considerable challenges to high resolution structural analysis. Maintaining membrane proteins in their native state during protein isolation is essential for structural study of these bio‐macromolecules. Detergents are the most commonly used amphiphilic compounds for...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2022-04, Vol.23 (7), p.e202200027-n/a
Main Authors: Ehsan, Muhammad, Wang, Haoqing, Katsube, Satoshi, Munk, Chastine F., Du, Yang, Youn, Taeyeol, Yoon, Soyoung, Byrne, Bernadette, Loland, Claus J., Guan, Lan, Kobilka, Brian K., Chae, Pil Seok
Format: Article
Language:English
Subjects:
Cholesterol
Coupling
detergent design
detergent-detergent interactions
Detergents
Detergents - chemistry
glyco-steroids
glycolipids
Hydrophobic and Hydrophilic Interactions
Integral membrane proteins
Lipid bilayers
Lipids
Macromolecules
Membrane Proteins - chemistry
Membranes
Protein Stability
protein stabilization
Protein structure
Proteins
Stabilization
Steroids
Structural analysis
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