Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARγ/SIRT1-Mediated NF-κB Pathway

Chitosan oligosaccharides (COS) have been shown to have potential protective effects against colitis, but the mechanism underlying this effect has not been fully elucidated. In this study, COS were found to significantly attenuate dextran sodium sulfate-induced colitis in mice by decreasing disease...

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Published in:	Marine drugs 2022-01, Vol.20 (2), p.96
Main Authors:	Guo, Congcong, Zhang, Yue, Ling, Tao, Zhao, Chongjie, Li, Yanru, Geng, Meng, Gai, Sailun, Qi, Wei, Luo, Xuegang, Chen, Liehuan, Zhang, Tongcun, Wang, Nan
Format:	Article
Language:	English
Subjects:	Abundance Acetylation Animals antagonists Bacteroidetes butyrates Cells Chitosan Chitosan - pharmacology chitosan oligosaccharides Colitis Colitis - drug therapy Colitis - microbiology Cytokines Dextran Dextrans Disease Models, Animal Gastrointestinal Microbiome - drug effects Inflammation Inflammatory bowel disease Interleukin 6 intestinal microbiota Intestinal microflora intestinal microorganisms Intestine Lactobacillus Lipopolysaccharides Lysine Male Mice Mice, Inbred C57BL Microbiota Mucin NF-kappa B - metabolism NF-κB NF-κB protein Nitric oxide Oligosaccharides Oligosaccharides - pharmacology Peroxisome proliferator-activated receptors Phosphorylation PPAR gamma - metabolism PPARγ Propionic acid Proteins RAW 264.7 Cells Signal transduction Signal Transduction - drug effects siRNA SIRT1 SIRT1 protein Sirtuin 1 - metabolism Sodium Sodium sulfate Synaptotagmin Tumor necrosis factor-TNF ulcerative colitis
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